There is a clear and definite conflict between what Buddhism teaches and how we are encouraged to think and act in our society. Our society is driven by capitalism and greed. We are taught, from an early age, that we need to buy more, eat more, acquire more "stuff" - more, more, more!!! Even those people who are wealthy often say they need more money to be happy, so clearly, obtaining materialistic wealth does not lead to happiness or satisfaction.
Unfortunately, since money is the driving force behind almost everything, if everyone in America were to suddenly give up all there desires, our country would collapse financially. But maybe we'd all be a lot happier and satisfied!
Secondly, even holding on to people or believing that a certain job might make you happier can lead to a false sense of satisfaction. If one truly accepted that losing someone to death, or having someone you loved leave you, is a fact of life and is unavoidable, then that person would live a more fulfilling life and not get caught up in their negative emotions. They will certainly feel the negative emotions but they would be able to let them pass, and then move on. I certainly need to practice what I have just said more often in my personal experience.